Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 2/20 | 0.32 |
| ▸ | MMP9 | P14780 | 2/20 | 0.32 |
| ▸ | MMP13 | P45452 | 2/20 | 0.32 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | C5 | P01031 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8335608 | 0.99 | SMPD1 (0.34) | SMN1; SMN2CYP3A4SMPD1MMP1MMP9 | |
| SCHEMBL8338614 | 0.97 | SMN1; SMN2 (0.35) | SMN1; SMN2SMPD1GAATDP1L3MBTL1 | |
| SCHEMBL8389248 | 0.94 | TAS1R3 (0.32) | SMN1; SMN2ALDH1A1GLAMAPTNPSR1 | |
| SCHEMBL8337752 | 0.93 | SMN1; SMN2 (0.35) | SMN1; SMN2CYP3A4SMPD1MMP1MMP9 | |
| SCHEMBL8336318 | 0.92 | SMPD1 (0.35) | SMN1; SMN2CYP3A4SMPD1MMP1MMP9 | |
| SCHEMBL8340225 | 0.91 | SMN1; SMN2 (0.33) | SMN1; SMN2CYP3A4SMPD1MMP1MMP9 | |
| SCHEMBL8335692 | 0.91 | SMN1; SMN2 (0.35) | SMN1; SMN2CYP3A4SMPD1MMP1MMP9 | |
| SCHEMBL8340001 | 0.90 | SMN1; SMN2 (0.36) | SMN1; SMN2SMPD1GAATDP1L3MBTL1 | |
| SCHEMBL8333752 | 0.90 | HIF1A (0.34) | SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL8333029 | 0.89 | ALDH1A1 (0.31) | ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977177-A | Substituted benzenesulfonylureas and-thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds, and medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-11-02 | — | — | US | disclosed |
| US-5880155-A | TREATMENT OF CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-03-09 | — | — | US | disclosed |