Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 4/20 | 0.32 |
| ▸ | TAS1R1 | Q7RTX1 | 4/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 2/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8338614 | 0.94 | SMN1; SMN2 (0.35) | TAS1R3TAS1R1SMN1; SMN2GLAHIF1A | |
| SCHEMBL8338441 | 0.94 | SMN1; SMN2 (0.34) | SMN1; SMN2GLAALDH1A1MAPTNPSR1 | |
| SCHEMBL8335608 | 0.93 | SMPD1 (0.34) | SMN1; SMN2 | |
| SCHEMBL8336029 | 0.92 | TAS1R3 (0.33) | TAS1R3TAS1R1SMN1; SMN2GLAHIF1A | |
| SCHEMBL8333752 | 0.92 | HIF1A (0.34) | SMN1; SMN2HIF1AALDH1A1MAPTLMNA | |
| SCHEMBL8340685 | 0.91 | SMN1; SMN2 (0.33) | TAS1R3TAS1R1SMN1; SMN2GLAHIF1A | |
| SCHEMBL8336132 | 0.88 | — | — | |
| SCHEMBL8336357 | 0.88 | HIF1A (0.34) | SMN1; SMN2HIF1AALDH1A1MAPTLMNA | |
| SCHEMBL8340225 | 0.88 | SMN1; SMN2 (0.33) | TAS1R3TAS1R1SMN1; SMN2GLAALDH1A1 | |
| SCHEMBL8334835 | 0.88 | GAA (0.31) | HIF1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977177-A | Substituted benzenesulfonylureas and-thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds, and medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-11-02 | — | — | US | disclosed |
| US-5880155-A | TREATMENT OF CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-03-09 | — | — | US | disclosed |