Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8339878 | 0.92 | ALDH1A1 (0.33) | ALDH1A1MEN1KMT2AKDM4ELMNA | |
| SCHEMBL8340341 | 0.90 | KDM4E (0.36) | ALDH1A1MEN1KMT2AKDM4ELMNA | |
| SCHEMBL8335548 | 0.89 | KDM4E (0.35) | ALDH1A1MEN1KMT2AKDM4ELMNA | |
| SCHEMBL8341296 | 0.88 | TDP1 (0.40) | ALDH1A1KMT2AKDM4ELMNAGAA | |
| SCHEMBL8338337 | 0.86 | GAA (0.35) | ALDH1A1MEN1KMT2AKDM4ELMNA | |
| SCHEMBL8338207 | 0.81 | TDP1 (0.37) | ALDH1A1KDM4ELMNAGAASMN1; SMN2 | |
| SCHEMBL8339028 | 0.80 | GAA (0.33) | ALDH1A1MEN1KMT2AKDM4ELMNA | |
| SCHEMBL8340160 | 0.79 | MAPT (0.37) | ALDH1A1MEN1KMT2ALMNAGAA | |
| SCHEMBL8338140 | 0.79 | MMP9 (0.38) | ALDH1A1MEN1KMT2AKDM4EGAA | |
| SCHEMBL8338089 | 0.79 | TDP1 (0.37) | ALDH1A1MEN1KMT2AKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977177-A | Substituted benzenesulfonylureas and-thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds, and medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-11-02 | — | — | US | disclosed |
| US-5880155-A | TREATMENT OF CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-03-09 | — | — | US | disclosed |