Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ACACB | O00763 | 6/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | PLK1 | P53350 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ACACA | Q13085 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8339955 | 0.90 | POLB (0.39) | MAPTNPSR1ALDH1A1LMNAALOX12 | |
| SCHEMBL8338089 | 0.90 | TDP1 (0.37) | MAPTALDH1A1LMNAALOX12HPGD | |
| SCHEMBL8338207 | 0.84 | TDP1 (0.37) | MAPTALDH1A1LMNAHPGDCNR2 | |
| SCHEMBL8341296 | 0.83 | TDP1 (0.40) | MAPTALDH1A1LMNAHPGDCNR2 | |
| SCHEMBL8338140 | 0.82 | MMP9 (0.38) | MAPTALDH1A1POLBHPGDGAA | |
| SCHEMBL8334670 | 0.82 | MMP9 (0.41) | POLBHTT | |
| SCHEMBL8339878 | 0.81 | ALDH1A1 (0.33) | ALDH1A1LMNAGAAHTTMEN1 | |
| SCHEMBL8334100 | 0.80 | POLB (0.41) | MAPTLMNAPOLBACACBPLK1 | |
| SCHEMBL8338863 | 0.79 | ALDH1A1 (0.35) | ALDH1A1LMNACNR2GAAHTT | |
| SCHEMBL8340341 | 0.79 | KDM4E (0.36) | ALDH1A1LMNAGAAHTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977177-A | Substituted benzenesulfonylureas and-thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds, and medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-11-02 | — | — | US | disclosed |
| US-5880155-A | TREATMENT OF CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-03-09 | — | — | US | disclosed |