SCHEMBL8338939

SCHEMBL8338939

COC=C(C(=O)OOc1cccc(Oc2cccc(C#N)c2)c1)c1ccccc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
P4HB P07237 1/20 0.42
AKR1C3 P42330 1/20 0.40
HDAC8 Q9BY41 1/20 0.37
PGR P06401 2/20 0.37
ALOX5 P09917 1/20 0.36
GRM5 P41594 2/20 0.36
ALDH1A1 P00352 2/20 0.36
P2RY2 P41231 1/20 0.36
GPR17 Q13304 1/20 0.36
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
PDE4A P27815 3/20 0.36
PDE4B Q07343 3/20 0.36
PDE4C Q08493 3/20 0.36
PDE4D Q08499 3/20 0.36
RECQL P46063 1/20 0.36
TLR4 O00206 1/20 0.36
TLR2 O60603 1/20 0.36
ERCC5 P28715 1/20 0.35
FEN1 P39748 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8338930 1.00 P4HB (0.42) P4HBAKR1C3HDAC8PGRALOX5
SCHEMBL2107655 0.80 MEN1 (0.51) AKR1C3PGRALDH1A1MEN1KMT2A
SCHEMBL2107651 0.80 MEN1 (0.51) AKR1C3PGRALDH1A1MEN1KMT2A
SCHEMBL29359347 0.79 ALDH1A1 (0.42) ALDH1A1MEN1KMT2ARECQLGAA
SCHEMBL2108447 0.79 GCK (0.41) AKR1C3PGRALDH1A1MEN1KMT2A
SCHEMBL2108453 0.79 GCK (0.41) AKR1C3PGRALDH1A1MEN1KMT2A
SCHEMBL2107664 0.79 KDM4E (0.56) PGRALDH1A1MEN1KMT2ATLR4
SCHEMBL2107667 0.79 KDM4E (0.56) PGRALDH1A1MEN1KMT2ATLR4
SCHEMBL8338935 0.78 AKR1C3 (0.44) P4HBAKR1C3HDAC8PGRALOX5
SCHEMBL2106908 0.77 MEN1 (0.40) AKR1C3PGRALDH1A1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5925675-A N-sulfonyliminodithio compounds useful for in plant and material protection BAYER AKTIENGESELLSCHAFT (DE) 1999-07-20 US disclosed
US-5874025-A Timber preservative containing a copper compound BAYER AKTIENGESELLSCHAFT (DE) 1999-02-23 US disclosed
US-5767137-A FOR INDUSTRIAL MATERIALS BAYER AKTIENGESELLSCHAFT (DE) 1998-06-16 US disclosed
US-5703103-A MICROBIOCIDES BAYER AKTIENGESELLSCHAFT (DE) 1997-12-30 US disclosed
US-5672617-A Medicaments containing 1-thiocarbamoyl-5-hydroxy-pyrazoles and their use as agents for combating septic shock BAYER AKTIENGESELLSCHAFT (DE) 1997-09-30 US disclosed