SCHEMBL8338941

SCHEMBL8338941

O=C(O)c1sc(-c2ccc(C(F)(F)F)cc2)nc1C(F)(F)F

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.54
NPC1 O15118 2/20 0.54
GAA P10253 2/20 0.54
PPARA Q07869 8/20 0.54
PPARD Q03181 5/20 0.54
PPARG P37231 4/20 0.54
KDM4E B2RXH2 3/20 0.52
MEN1 O00255 1/20 0.52
HSP90AA1 P07900 1/20 0.52
MAPT P10636 1/20 0.52
CRHBP P24387 1/20 0.52
KMT2A Q03164 1/20 0.52
CRHR2 Q13324 1/20 0.52
SMN1; SMN2 Q16637 3/20 0.51
NR1H4 Q96RI1 1/20 0.49
RAB9A P51151 2/20 0.49
POLB P06746 1/20 0.49
CDC7 O00311 2/20 0.47
DBF4 Q9UBU7 2/20 0.47
FFAR1 O14842 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16703796 0.88 SMN1; SMN2 (0.49) ALDH1A1NPC1GAAPPARAPPARD
SCHEMBL8341574 0.88 SMN1; SMN2 (0.64) ALDH1A1NPC1GAAPPARAPPARD
SCHEMBL4497703 0.88 SMN1; SMN2 (0.59) ALDH1A1NPC1GAAKDM4EMEN1
SCHEMBL24303680 0.87 RAB9A (0.48) ALDH1A1NPC1GAAPPARAPPARD
SCHEMBL873941 0.87 RAB9A (0.48) ALDH1A1NPC1GAAPPARAPPARD
SCHEMBL981341 0.84 SMN1; SMN2 (0.71) ALDH1A1NPC1GAAPPARAPPARD
SCHEMBL8338965 0.83 SMN1; SMN2 (0.45) ALDH1A1NPC1GAAPPARAPPARD
SCHEMBL5899944 0.81 KDM4E (0.55) ALDH1A1NPC1GAAPPARAPPARD
SCHEMBL4475694 0.80 ALDH1A1 (0.53) ALDH1A1NPC1GAAPPARAPPARD
SCHEMBL8341363 0.80 MAPT (0.78) ALDH1A1NPC1GAAPPARAPPARD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2015069011-A1 NOVEL COMPOUND, METHOD FOR PREPARATION THEREOF, AND ANTIFUNGAL COMPOSITION COMPRISING THE SAME DAEWOONG PHARMACEUTICAL CO., LTD. (KR) 2015-05-14 WO disclosed
US-5888941-A Carbozamides with antifungal activity J. URIACH & CIA. S.A. (ES) 1999-03-30 US disclosed
EP-0783502-A1 NEW CARBOXAMIDES WITH ANTIFUNGAL ACTIVITY J. URIACH & CIA. S.A. (ES) 1997-07-16 EP disclosed
WO-1997005131-A1 NEW CARBOXAMIDES WITH ANTIFUNGAL ACTIVITY J. URIACH & CIA. S.A. (ES) 1997-02-13 WO disclosed