Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | GPR3 | P46089 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.35 |
| ▸ | OGG1 | O15527 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9270189 | 0.80 | CYP1A2 (0.48) | LOXL2GPR3EGFRSRCALDH1A1 | |
| SCHEMBL11532670 | 0.76 | L3MBTL1 (0.39) | GPR3EGFRSRCALDH1A1LMNA | |
| SCHEMBL10364177 | 0.76 | GPR3 (0.44) | LOXL2GPR3ALDH1A1MCL1OGG1 | |
| SCHEMBL9272736 | 0.75 | EGFR (0.43) | LOXL2GPR3EGFRSRCALDH1A1 | |
| SCHEMBL11311400 | 0.71 | EGFR (0.52) | EGFRSRCALDH1A1LMNAHTT | |
| SCHEMBL5763556 | 0.70 | MCL1 (0.49) | LOXL2EGFRALDH1A1LMNAMCL1 | |
| SCHEMBL10735490 | 0.69 | EGFR (0.50) | EGFRSRCALDH1A1LMNAHTT | |
| SCHEMBL17072313 | 0.68 | LOXL2 (0.41) | LOXL2GPR3EGFRSRCALDH1A1 | |
| SCHEMBL18301165 | 0.68 | EGFR (0.63) | GPR3EGFRSRCALDH1A1LMNA | |
| SCHEMBL28322189 | 0.68 | LOXL2 (0.57) | LOXL2GPR3ALDH1A1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6001860-A | N-aryl and N-heteroarylurea derivatives as inhibitors of acyl coenzyme A: Cholesterol acyl transferase (ACAT) | PFIZER INC. (US) | 1999-12-14 | — | — | US | disclosed |
| EP-0642498-A1 | NEW $i(N)-ARYL AND $i(N)-HETEROARYLUREA DERIVATIVES AS INHIBITORS OF ACYL COENZYME A:CHOLESTEROL ACYL TRANSFERASE (ACAT) | PFIZER INC. (US) | 1995-03-15 | — | — | EP | disclosed |
| WO-1993024458-A1 | NEW N-ARYL AND N-HETEROARYLUREA DERIVATIVES AS INHIBITORS OF ACYL COENZYME A:CHOLESTEROL ACYL TRANSFERASE (ACAT) | PFIZER INC. (US) | 1993-12-09 | — | — | WO | disclosed |