Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TOP2A | P11388 | 8/20 | 0.38 |
| ▸ | FNTA | P49354 | 1/20 | 0.36 |
| ▸ | FNTB | P49356 | 1/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | USP8 | P40818 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.34 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8336928 | 0.87 | ADORA2A (0.42) | MAOAMEN1KMT2AMAPTTOP2A | |
| SCHEMBL8336811 | 0.85 | TOP2A (0.45) | MAOAMEN1KMT2AMAPTTOP2A | |
| SCHEMBL8172006 | 0.83 | EIF2AK2 (0.54) | MAOAMEN1KMT2AMAPTTOP2A | |
| SCHEMBL8337451 | 0.76 | TOP2A (0.45) | MEN1KMT2AMAPTTOP2AMAPK13 | |
| SCHEMBL8340204 | 0.73 | TOP2A (0.41) | KMT2AMAPTTOP2AMAPK13EIF2AK2 | |
| SCHEMBL10800769 | 0.67 | TOP2A (0.38) | MAOAMAPTTOP2ASMN1; SMN2 | |
| SCHEMBL10805231 | 0.65 | TOP2A (0.54) | MEN1KMT2AMAPTTOP2AFNTA | |
| SCHEMBL18984751 | 0.64 | CYP19A1 (0.51) | MAOAMEN1KMT2AMAPTTOP2A | |
| SCHEMBL4399257 | 0.64 | CYP19A1 (0.51) | MAOAMEN1KMT2AMAPTTOP2A | |
| SCHEMBL10801104 | 0.63 | TOP2A (0.54) | TOP2AFNTAFNTBMAPK13EIF2AK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7335676-B2 | Methods for treating inflammatory conditions or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-02-26 | — | — | US | disclosed |
| WO-2004084891-A1 | METHODS FOR TREATING INFLAMMATORY CONDITIONS OR INHIBITING JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2004-10-07 | — | — | WO | disclosed |