Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 12/20 | 0.41 |
| ▸ | S100A4 | P26447 | 2/20 | 0.38 |
| ▸ | PTPRC | P08575 | 1/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8338787 | 0.86 | POLB (0.39) | TOP2AS100A4PTPRCMAPK13EIF2AK2 | |
| SCHEMBL8337451 | 0.83 | TOP2A (0.45) | TOP2AMAPK13EIF2AK2MAPK12MAPK11 | |
| SCHEMBL8336811 | 0.83 | TOP2A (0.45) | TOP2AMAPK13EIF2AK2MAPK12MAPK11 | |
| SCHEMBL8172006 | 0.82 | EIF2AK2 (0.54) | TOP2AMAPK13EIF2AK2MAPK12MAPK11 | |
| SCHEMBL8340182 | 0.73 | MAOA (0.38) | TOP2AMAPK13EIF2AK2MAPK12MAPK11 | |
| SCHEMBL8336928 | 0.73 | ADORA2A (0.42) | TOP2APTPRCMAPK13EIF2AK2MAPK12 | |
| SCHEMBL25173418 | 0.66 | NPC1 (0.32) | RECQL | |
| SCHEMBL25458468 | 0.65 | DCTPP1 (0.31) | RECQL | |
| SCHEMBL2347136 | 0.65 | S100A4 (0.84) | S100A4PTPRCAURKAMAPTRECQL | |
| SCHEMBL14910262 | 0.65 | KDR (0.37) | MAPTRECQLKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7335676-B2 | Methods for treating inflammatory conditions or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-02-26 | — | — | US | disclosed |
| WO-2004084891-A1 | METHODS FOR TREATING INFLAMMATORY CONDITIONS OR INHIBITING JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2004-10-07 | — | — | WO | disclosed |