Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 12/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 2/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8336811 | 0.87 | TOP2A (0.45) | TOP2AMAPK13EIF2AK2MAPK12MAPK11 | |
| SCHEMBL8172006 | 0.85 | EIF2AK2 (0.54) | TOP2AMAPK13EIF2AK2MAPK12MAPK11 | |
| SCHEMBL8336928 | 0.85 | ADORA2A (0.42) | TOP2AMAPK13EIF2AK2MAPK12MAPK11 | |
| SCHEMBL8340204 | 0.83 | TOP2A (0.41) | TOP2AMAPK13EIF2AK2MAPK12MAPK11 | |
| SCHEMBL8340182 | 0.76 | MAOA (0.38) | TOP2AMAPK13EIF2AK2MAPK12MAPK11 | |
| SCHEMBL8338787 | 0.73 | POLB (0.39) | TOP2AMAPK13EIF2AK2MAPK12MAPK11 | |
| SCHEMBL10812034 | 0.66 | ADORA2A (0.51) | ADORA2ARAB9AATMNPC1MEN1 | |
| SCHEMBL13959447 | 0.65 | TOP2A (0.63) | TOP2AMAPK13EIF2AK2MAPK12MAPK11 | |
| SCHEMBL13959446 | 0.65 | TOP2A (0.76) | TOP2AMAPK13EIF2AK2MAPK12MAPK11 | |
| SCHEMBL8176664 | 0.64 | EIF2AK2 (0.66) | TOP2AMAPK13EIF2AK2MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7335676-B2 | Methods for treating inflammatory conditions or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-02-26 | — | — | US | disclosed |
| WO-2004084891-A1 | METHODS FOR TREATING INFLAMMATORY CONDITIONS OR INHIBITING JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2004-10-07 | — | — | WO | disclosed |