Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK2 | P19525 | 2/20 | 0.54 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.54 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.54 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.54 |
| ▸ | TOP2A | P11388 | 9/20 | 0.40 |
| ▸ | USP8 | P40818 | 1/20 | 0.37 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | APEX1 | P27695 | 2/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8336811 | 0.85 | TOP2A (0.45) | EIF2AK2MAPK12MAPK13MAPK11MAPK14 | |
| SCHEMBL8337451 | 0.85 | TOP2A (0.45) | EIF2AK2MAPK12MAPK13MAPK11MAPK14 | |
| SCHEMBL8340182 | 0.83 | MAOA (0.38) | EIF2AK2MAPK12MAPK13MAPK11MAPK14 | |
| SCHEMBL8336928 | 0.83 | ADORA2A (0.42) | EIF2AK2MAPK12MAPK13MAPK11MAPK14 | |
| SCHEMBL8340204 | 0.82 | TOP2A (0.41) | EIF2AK2MAPK12MAPK13MAPK11MAPK14 | |
| SCHEMBL8338787 | 0.80 | POLB (0.39) | EIF2AK2MAPK12MAPK13MAPK11MAPK14 | |
| SCHEMBL8176664 | 0.79 | EIF2AK2 (0.66) | EIF2AK2MAPK12MAPK13MAPK11MAPK14 | |
| SCHEMBL11120339 | 0.74 | EIF2AK2 (0.62) | EIF2AK2MAPK12MAPK13MAPK11MAPK14 | |
| SCHEMBL8171875 | 0.71 | EIF2AK2 (1.00) | EIF2AK2MAPK12MAPK13MAPK11MAPK14 | |
| SCHEMBL4846358 | 0.70 | EIF2AK2 (0.53) | EIF2AK2MAPK12MAPK13MAPK11MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008091925-A2 | TREATMENT OF AORTIC DISSECTION OR ANEURYSM | COOK INCORPORATED (US) | 2008-07-31 | — | — | WO | disclosed |