Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.50 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.50 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.50 |
| ▸ | KIT | P10721 | 2/20 | 0.50 |
| ▸ | FLT3 | P36888 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | CDC7 | O00311 | 1/20 | 0.50 |
| ▸ | PLK4 | O00444 | 1/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.50 |
| ▸ | IKBKB | O14920 | 1/20 | 0.50 |
| ▸ | RGS12 | O14924 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | GAK | O14976 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.50 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.50 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14277268 | 0.86 | TTK (0.52) | KDRALDH1A1KDM4EMAPK8MAPK9 | |
| SCHEMBL8336736 | 0.86 | CYP1A2 (0.52) | KDRALDH1A1KDM4EMAPK8MAPK9 | |
| SCHEMBL8339586 | 0.84 | TTK (0.53) | KDRALDH1A1KDM4EMAPK8MAPK9 | |
| SCHEMBL8337967 | 0.84 | KDR (0.47) | KDRALDH1A1KDM4EMAPK8MAPK9 | |
| SCHEMBL8172258 | 0.79 | MAPK8 (0.56) | KDRALDH1A1KDM4EMAPK8MAPK9 | |
| SCHEMBL7791992 | 0.77 | HTR7 (0.54) | ALDH1A1KDM4EHTR7SMN1; SMN2HTR1B | |
| SCHEMBL8338946 | 0.77 | TTK (0.50) | KDRALDH1A1KDM4EMAPK8MAPK9 | |
| SCHEMBL8342541 | 0.75 | CDK2 (0.60) | KDRALDH1A1KDM4EMAPK8MAPK9 | |
| SCHEMBL5251497 | 0.75 | ALDH1A1 (0.48) | KDRALDH1A1KDM4EMAPK8MAPK9 | |
| Hydrochloric Acid SCHEMBL11606266 | 0.75 | KCNA3 (0.61) | ALDH1A1KDM4ELMNAMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7335676-B2 | Methods for treating inflammatory conditions or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-02-26 | — | — | US | disclosed |
| US-7335676-B2 | Methods for treating inflammatory conditions or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-02-26 | — | — | US | disclosed |
| WO-2004084891-A1 | METHODS FOR TREATING INFLAMMATORY CONDITIONS OR INHIBITING JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2004-10-07 | — | — | WO | disclosed |