Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | GALR2 | O43603 | 1/20 | 0.35 |
| ▸ | GALR1 | P47211 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3236256 | 0.88 | DRD2 (0.48) | HTR2AKMT2ADRD2DRD3DRD4 | |
| SCHEMBL3240312 | 0.88 | GALR2 (0.50) | HTR2ADRD2DRD3DRD4ALDH1A1 | |
| SCHEMBL3241396 | 0.85 | LMNA (0.43) | DRD2DRD3DRD4ALDH1A1CYP1A2 | |
| SCHEMBL6788475 | 0.78 | CASP1 (0.45) | HTR2AALDH1A1GALR2GALR1LMNA | |
| SCHEMBL6789057 | 0.78 | LMNA (0.51) | GPR6LMNA | |
| SCHEMBL6790565 | 0.77 | KDM4E (0.50) | HTR2AKMT2ADRD2DRD3DRD4 | |
| SCHEMBL6791198 | 0.76 | CASP1 (0.57) | HTR2AKMT2ADRD2DRD3DRD4 | |
| SCHEMBL8254499 | 0.76 | CASP1 (0.43) | HTR2AALDH1A1GALR2GALR1LMNA | |
| SCHEMBL6788494 | 0.76 | KDM4E (0.48) | HTR2AKMT2AALDH1A1GALR2GALR1 | |
| SCHEMBL6797121 | 0.75 | GALR2 (0.54) | HTR2ADRD2DRD3DRD4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004014376-A1 | GAL3 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF AFFECTIVE DISORDERS | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2004-02-19 | — | — | WO | disclosed |