Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.52 |
| ▸ | MMP2 | P08253 | 3/20 | 0.47 |
| ▸ | MMP3 | P08254 | 2/20 | 0.47 |
| ▸ | MMP1 | P03956 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 2/20 | 0.45 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.42 |
| ▸ | KMO | O15229 | 1/20 | 0.42 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7861733 | 0.90 | TSHR (0.66) | TSHRGRIK1MMP2MMP3MMP1 | |
| SCHEMBL6411354 | 0.84 | TSHR (0.54) | TSHRGRIK1MMP2MMP3MMP1 | |
| SCHEMBL7861850 | 0.83 | TSHR (0.53) | TSHRGRIK1MMP2MMP3MMP1 | |
| SCHEMBL27472081 | 0.81 | GRIK1 (0.52) | TSHRGRIK1MMP2MMP3MMP1 | |
| SCHEMBL7352438 | 0.80 | MMP2 (0.60) | TSHRGRIK1MMP2MMP3MMP1 | |
| SCHEMBL7371830 | 0.80 | MMP2 (0.60) | TSHRGRIK1MMP2MMP3MMP1 | |
| SCHEMBL7347169 | 0.80 | MMP2 (0.60) | TSHRGRIK1MMP2MMP3MMP1 | |
| SCHEMBL7319632 | 0.79 | GRIK1 (0.64) | GRIK1MMP2MMP3CPB2 | |
| SCHEMBL1856639 | 0.78 | GRIK1 (0.72) | GRIK1MMP2MMP3MMP1MMP9 | |
| SCHEMBL27613201 | 0.77 | TDP1 (0.77) | NPC1CASP3RAB9ASENP8SENP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5948780-A | ADMINISTERING A METALLOPROTEINASE INHIBITOR | WARNER-LAMBERT COMPANY (US) | 1999-09-07 | — | — | US | disclosed |
| US-5789434-A | ACID, ESTER OR AMIDE DERIVATIVES AS ANTIINFLAMMATORY AGENTS, ANTIARTHRITIC AGENTS AND REDUCTION OF CARTILAGE DETERIORATION | BAYER CORPORATION (US) | 1998-08-04 | — | — | US | disclosed |