Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.68 |
| ▸ | MEN1 | O00255 | 3/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.32 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8342323 | 0.86 | LMNA (0.72) | LMNAALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL8342494 | 0.86 | LMNA (0.75) | LMNAALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL9369302 | 0.85 | LMNA (0.78) | LMNAALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL9365729 | 0.84 | LMNA (0.72) | LMNAALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL9365789 | 0.84 | KMT2A (0.72) | LMNAALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL9365388 | 0.84 | LMNA (0.72) | LMNAALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL29624123 | 0.84 | KMT2A (0.72) | LMNAALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL8343305 | 0.83 | LMNA (0.68) | LMNAALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL9366677 | 0.81 | ALDH1A1 (1.00) | LMNAALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL9365701 | 0.81 | LMNA (0.79) | LMNAALDH1A1KMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5939435-A | TREATMENT OF ATHEROSCLEROSIS AND CORONARY HEART DISEASE | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-08-17 | — | — | US | disclosed |