Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | DRD1 | P21728 | 1/20 | 0.45 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PDE5A | O76074 | 2/20 | 0.42 |
| ▸ | PDE9A | O76083 | 2/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | PLK1 | P53350 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7478166 | 0.80 | PDE5A (0.50) | MEN1KMT2APDE5APDE9A | |
| SCHEMBL8345718 | 0.80 | MEN1 (0.51) | MEN1KMT2APDE5APDE9A | |
| SCHEMBL5545647 | 0.79 | HTR7 (0.55) | MEN1KMT2APARP1 | |
| SCHEMBL24335140 | 0.78 | PDE5A (0.48) | MEN1KMT2APDE5APDE9APLK1 | |
| SCHEMBL29580737 | 0.78 | PDE5A (0.48) | MEN1KMT2APDE5APDE9APLK1 | |
| SCHEMBL8117343 | 0.78 | MEN1 (0.47) | MEN1KMT2APDE5APDE9ARAB9A | |
| SCHEMBL9544064 | 0.77 | GRIA1 (0.55) | MEN1KMT2APDE5APDE9A | |
| SCHEMBL8346269 | 0.77 | MEN1 (0.46) | MEN1KMT2APDE5APDE9ARAB9A | |
| SCHEMBL13801880 | 0.76 | HTR7 (0.47) | KCNH2ABCB11HTR1AADRA2AADORA3 | |
| SCHEMBL8118534 | 0.75 | MEN1 (0.45) | KCNH2ABCB11HTR1AADRA2AADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5955461-A | Quinoxalinedione derivatives, their production and use in pharmaceutical agents | SCHERING AKTIENGESELLSCHAFT (DE) | 1999-09-21 | — | — | US | disclosed |
| US-5750525-A | Quinoxalinedione derivatives, their production and use in pharmaceutical agents | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-05-12 | — | — | US | disclosed |