Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 9/20 | 0.59 |
| ▸ | MGMT | P16455 | 4/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | TPO | P07202 | 1/20 | 0.59 |
| ▸ | EPX | P11678 | 1/20 | 0.59 |
| ▸ | CDK1 | P06493 | 2/20 | 0.52 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.52 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.52 |
| ▸ | CDK2 | P24941 | 2/20 | 0.52 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.52 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8723557 | 0.81 | MPO (0.54) | MPOMGMTCYP3A4TPOEPX | |
| SCHEMBL8006001 | 0.81 | MPO (0.51) | MPOMGMTCYP3A4TPOEPX | |
| 6-O-Benzylguanine SCHEMBL29405347 | 0.80 | MGMT (0.63) | MPOMGMTCYP3A4TPOEPX | |
| 6-O-Benzylguanine SCHEMBL600698 | 0.80 | MGMT (0.63) | MPOMGMTCYP3A4TPOEPX | |
| 6-O-Benzylguanine SCHEMBL4631743 | 0.79 | MGMT (0.61) | MPOMGMTCYP3A4TPOEPX | |
| SCHEMBL19295446 | 0.79 | MPO (0.58) | MPOMGMTCYP3A4TPOEPX | |
| SCHEMBL21878057 | 0.78 | MPO (0.48) | MPOMGMTCYP3A4TPOEPX | |
| SCHEMBL3300895 | 0.77 | PIN1 (0.67) | MPOMGMTCYP3A4TPOEPX | |
| SCHEMBL16852229 | 0.76 | MGMT (0.64) | MPOMGMTCYP3A4TPOEPX | |
| SCHEMBL3300630 | 0.75 | MGMT (0.56) | MPOMGMTCYP3A4TPOEPX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120252791-A1 | Heterocyclic GTP Cyclohydrolase 1 Inhibitors For the Treatment of Pain | CHILDREN'S MEDICAL CENTER CORPORATION | 2012-10-04 | — | — | US | disclosed |
| US-5912252-A | Purine and guanine derivatives as PNP inhibitors | DARWIN DISCOVERY LIMITED (GB) | 1999-06-15 | — | — | US | disclosed |
| EP-0873339-A1 | PURINE AND GUANINE DERIVATIVES AS PNP INHIBITORS | Chiroscience Limited (GB) | 1998-10-28 | — | — | EP | disclosed |
| US-5736549-A | INHIBITORS OF PURINE NUCLEOSIDE PHOSPHORYLASE, USED FOR TREATING OR PREVENTING TISSUE REJECTION OR SELECTIVE SUPPRESSION OF MAMMALIAN T-CELL FUNCTION | CHIROSCIENCE LIMITED (GB) | 1998-04-07 | — | — | US | disclosed |
| EP-0784624-A1 | PURINE AND GUANINE COMPOUNDS AS INHIBITORS OF PNP | Chiroscience Limited (GB) | 1997-07-23 | — | — | EP | disclosed |
| WO-1997012887-A1 | PURINE AND GUANINE DERIVATIVES AS PNP INHIBITORS | CHIROSCIENCE LIMITED (GB) | 1997-04-10 | — | — | WO | disclosed |
| WO-1996011200-A1 | PURINE AND GUANINE COMPOUNDS AS INHIBITORS OF PNP | CHIROSCIENCE LIMITED (GB) | 1996-04-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120252791-A1 | Heterocyclic GTP Cyclohydrolase 1 Inhibitors For the Treatment of Pain | GGH, GGPS1, GGT1 | MPO 329/4885MGMT 1636/4885CYP3A4 1973/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.