Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 11/20 | 0.46 |
| ▸ | HPGD | P15428 | 10/20 | 0.46 |
| ▸ | NPC1 | O15118 | 9/20 | 0.46 |
| ▸ | RAB9A | P51151 | 9/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.46 |
| ▸ | MAPT | P10636 | 9/20 | 0.46 |
| ▸ | GAA | P10253 | 8/20 | 0.46 |
| ▸ | TP53 | P04637 | 7/20 | 0.46 |
| ▸ | GLA | P06280 | 4/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 8/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.44 |
| ▸ | RELA | Q04206 | 2/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | SNCA | P37840 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8344662 | 0.82 | KDM4E (0.40) | ALDH1A1SMN1; SMN2HPGDNPC1RAB9A | |
| SCHEMBL8346292 | 0.79 | F10 (0.43) | ALDH1A1SMN1; SMN2HPGDNPC1RAB9A | |
| SCHEMBL27606051 | 0.79 | F10 (0.43) | ALDH1A1SMN1; SMN2HPGDNPC1RAB9A | |
| SCHEMBL8344485 | 0.79 | RHEB (0.49) | ALDH1A1SMN1; SMN2HPGDNPC1RAB9A | |
| SCHEMBL8348316 | 0.79 | F10 (0.43) | ALDH1A1SMN1; SMN2HPGDNPC1RAB9A | |
| SCHEMBL28307753 | 0.79 | MEN1 (0.58) | ALDH1A1SMN1; SMN2HPGDNPC1RAB9A | |
| SCHEMBL3863014 | 0.78 | CSNK2A2 (0.49) | ALDH1A1SMN1; SMN2HPGDNPC1RAB9A | |
| SCHEMBL8344521 | 0.77 | NPBWR1 (0.50) | ALDH1A1SMN1; SMN2HPGDNPC1RAB9A | |
| SCHEMBL4687144 | 0.75 | F10 (0.40) | ALDH1A1SMN1; SMN2HPGDNPC1RAB9A | |
| SCHEMBL3861744 | 0.75 | F10 (0.47) | ALDH1A1HPGDKDM4EMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7566789-B2 | Benzimidazole derivatives | MERCK PATENT GMBH (DE) | 2009-07-28 | — | — | US | disclosed |
| US-7566789-B2 | Benzimidazole derivatives | MERCK PATENT GMBH (DE) | 2009-07-28 | — | — | US | disclosed |
| EP-1558247-B1 | BENZIMIDAZOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2008-02-20 | — | — | EP | disclosed |
| WO-2004017963-A1 | BENZIMIDAZOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2004-03-04 | — | — | WO | disclosed |