Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 11/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8344703 | 0.79 | ALDH1A1 (0.46) | F10PDE10AALDH1A1KDM4ENPC1 | |
| SCHEMBL27606051 | 0.78 | F10 (0.43) | F10PDE10AALDH1A1KDM4ENPC1 | |
| SCHEMBL3863014 | 0.77 | CSNK2A2 (0.49) | F10PDE10AALDH1A1KDM4ENPC1 | |
| SCHEMBL8344521 | 0.76 | NPBWR1 (0.50) | ALDH1A1NPC1HPGDNFKB1RAB9A | |
| SCHEMBL8346292 | 0.76 | F10 (0.43) | F10PDE10AALDH1A1KDM4ENPC1 | |
| SCHEMBL8344662 | 0.76 | KDM4E (0.40) | F10PDE10AALDH1A1KDM4ENPC1 | |
| SCHEMBL8344485 | 0.76 | RHEB (0.49) | F10PDE10AALDH1A1KDM4ENPC1 | |
| SCHEMBL29957251 | 0.75 | CYP2A6 (0.44) | ALDH1A1KDM4ENPC1HPGDRAB9A | |
| SCHEMBL3861744 | 0.74 | F10 (0.47) | F10ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL4687144 | 0.74 | F10 (0.40) | F10PDE10AALDH1A1KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7566789-B2 | Benzimidazole derivatives | MERCK PATENT GMBH (DE) | 2009-07-28 | — | — | US | disclosed |
| US-7566789-B2 | Benzimidazole derivatives | MERCK PATENT GMBH (DE) | 2009-07-28 | — | — | US | disclosed |
| EP-1558247-B1 | BENZIMIDAZOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2008-02-20 | — | — | EP | disclosed |
| WO-2004017963-A1 | BENZIMIDAZOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2004-03-04 | — | — | WO | disclosed |