Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 13/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.38 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27624772 | 0.92 | F10 (0.41) | F10KDM4EALDH1A1SMN1; SMN2GLA | |
| SCHEMBL8346713 | 0.85 | F10 (0.47) | F10KDM4EALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL27605913 | 0.84 | CA2 (0.46) | F10KDM4EALDH1A1GAANPSR1 | |
| SCHEMBL3863014 | 0.81 | CSNK2A2 (0.49) | F10KDM4EALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL8346380 | 0.78 | GAA (0.50) | F10KDM4EALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL3861744 | 0.78 | F10 (0.47) | F10KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL13759438 | 0.75 | F10 (0.43) | F10HDAC6 | |
| SCHEMBL8344703 | 0.75 | ALDH1A1 (0.46) | F10KDM4EALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL3865007 | 0.74 | F10 (0.40) | F10KDM4EALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL8346424 | 0.74 | SIRT2 (0.55) | KDM4EALDH1A1SMN1; SMN2MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1558247-B1 | BENZIMIDAZOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2008-02-20 | — | — | EP | disclosed |
| EP-1558247-A1 | BENZIMIDAZOLE DERIVATIVES | MERCK PATENT GmbH (DE) | 2005-08-03 | — | — | EP | disclosed |
| WO-2004017963-A1 | BENZIMIDAZOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2004-03-04 | — | — | WO | disclosed |