Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 3/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | ELANE | P08246 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | TYMS | P04818 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9629516 | 0.84 | METAP1 (0.41) | METAP1ACHEMAOAMAOBPARP10 | |
| SCHEMBL30933590 | 0.84 | METAP1 (0.41) | METAP1ACHEMAOAMAOBPARP10 | |
| SCHEMBL396140 | 0.76 | MAOA (0.50) | ACHEMAOAMAOBALDH1A1SMN1; SMN2 | |
| SCHEMBL14925847 | 0.75 | METAP1 (0.60) | METAP1ACHEMAOAMAOBPARP10 | |
| SCHEMBL1609651 | 0.75 | METAP1 (0.71) | METAP1ACHEMAOAMAOBPARP10 | |
| SCHEMBL787473 | 0.74 | MEN1 (0.37) | METAP1MAOAMAOBELANEALDH1A1 | |
| SCHEMBL6056920 | 0.74 | METAP1 (0.69) | METAP1ACHEMAOAMAOBPARP10 | |
| SCHEMBL6056983 | 0.72 | METAP1 (0.67) | METAP1ACHEMAOAMAOBPARP10 | |
| SCHEMBL1512741 | 0.72 | METAP1 (0.67) | METAP1ACHEMAOAMAOBPARP10 | |
| SCHEMBL28115385 | 0.72 | METAP1 (0.39) | METAP1ACHEMAOAMAOBPARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004014384-A2 | CYCLIC COMPOUNDS CONTAINING ZINC BINDING GROUPS AS MATRIX METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2004-02-19 | — | — | WO | disclosed |