SCHEMBL8345323

SCHEMBL8345323

CC(C)(C)c1ccc2oc(-c3ccc(C=Cc4ccc(-c5ccccc5)cc4)cc3)nc2c1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 6/20 0.57
RAB9A P51151 6/20 0.57
GFER P55789 2/20 0.57
SMN1; SMN2 Q16637 6/20 0.53
KDM4E B2RXH2 3/20 0.53
HPGD P15428 3/20 0.53
CASP3 P42574 2/20 0.53
SENP7 Q9BQF6 2/20 0.53
SENP6 Q9GZR1 2/20 0.53
POLB P06746 2/20 0.53
SENP8 Q96LD8 1/20 0.53
HDAC6 Q9UBN7 4/20 0.53
HDAC3 O15379 2/20 0.53
HDAC1 Q13547 2/20 0.53
HDAC2 Q92769 2/20 0.53
HDAC8 Q9BY41 2/20 0.53
ALDH1A1 P00352 3/20 0.46
TP53 P04637 2/20 0.46
HSD17B10 Q99714 1/20 0.46
GAA P10253 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11134813 1.00 NPC1 (0.57) NPC1RAB9AGFERSMN1; SMN2KDM4E
SCHEMBL29881441 1.00 NPC1 (0.57) NPC1RAB9AGFERSMN1; SMN2KDM4E
SCHEMBL7609481 0.96 NPC1 (0.59) NPC1RAB9AGFERSMN1; SMN2KDM4E
SCHEMBL14365418 0.96 NPC1 (0.59) NPC1RAB9AGFERSMN1; SMN2KDM4E
SCHEMBL7887297 0.94 NPC1 (0.64) NPC1RAB9AGFERSMN1; SMN2KDM4E
SCHEMBL7887300 0.94 NPC1 (0.64) NPC1RAB9AGFERSMN1; SMN2KDM4E
SCHEMBL7607309 0.93 NPC1 (0.57) NPC1RAB9AGFERSMN1; SMN2KDM4E
SCHEMBL7607314 0.93 NPC1 (0.57) NPC1RAB9AGFERSMN1; SMN2KDM4E
SCHEMBL3288218 0.92 NPC1 (0.66) NPC1RAB9AGFERSMN1; SMN2KDM4E
SCHEMBL2242175 0.89 NPC1 (0.65) NPC1RAB9AGFERSMN1; SMN2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1999015608-A1 SOFTENING COMPOSITIONS CONTAINING OPTICAL BRIGHTENERS 3V SIGMA S.P.A. (IT) 1999-04-01 WO claimed
EP-0006271-B2 WASHING AND SOFTENING COMPOSITIONS CONTAINING NONIONIC BRIGHTENER THE PROCTER & GAMBLE COMPANY (US) 1986-01-22 EP claimed
EP-0006271-B1 WASHING AND SOFTENING COMPOSITIONS CONTAINING NONIONIC BRIGHTENER THE PROCTER & GAMBLE COMPANY (US) 1982-03-31 EP claimed
EP-0006271-A1 Washing and softening compositions containing nonionic brightener THE PROCTER & GAMBLE COMPANY (US) 1980-01-09 EP claimed
US-7157547-B2 Ultraviolet blocking composition for protection of package or container contents EASTMAN CHEMICAL COMPANY (US) 2007-01-02 US disclosed
EP-0006271-B2 WASHING AND SOFTENING COMPOSITIONS CONTAINING NONIONIC BRIGHTENER THE PROCTER & GAMBLE COMPANY (US) 1986-01-22 EP disclosed
EP-0017618-B1 PROCESS FOR OPTICALLY BRIGHTENING POLYESTER FIBRES BY THE EXHAUST PROCESS CIBA-GEIGY AG (CH) 1983-03-02 EP disclosed
EP-0006271-B1 WASHING AND SOFTENING COMPOSITIONS CONTAINING NONIONIC BRIGHTENER THE PROCTER & GAMBLE COMPANY (US) 1982-03-31 EP disclosed
US-4283197-A Process for whitening polyester fibres by the exhaust method CIBA-GEIGY CORPORATION (US) 1981-08-11 US disclosed
EP-0006271-A1 Washing and softening compositions containing nonionic brightener THE PROCTER & GAMBLE COMPANY (US) 1980-01-09 EP disclosed
EP-0004121-A1 Low phosphate laundry detergent compositions THE PROCTER & GAMBLE COMPANY (US) 1979-09-19 EP disclosed