Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 10/20 | 0.45 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.43 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.43 |
| ▸ | MPL | P40238 | 2/20 | 0.41 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.41 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.41 |
| ▸ | BUB1 | O43683 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8345332 | 0.86 | TGFBR1 (0.59) | TGFBR1PRKD3PRKD1PRKD2BUB1 | |
| SCHEMBL8346587 | 0.84 | TGFBR1 (0.47) | TGFBR1PRKD3PRKD1PRKD2ACVR1B | |
| SCHEMBL8345885 | 0.83 | TGFBR1 (0.45) | TGFBR1PRKD3PRKD1PRKD2ACVR1B | |
| SCHEMBL8347168 | 0.82 | TGFBR1 (0.47) | TGFBR1PRKD3PRKD1PRKD2ACVR1B | |
| SCHEMBL8347025 | 0.81 | TGFBR1 (0.43) | TGFBR1PRKD3PRKD1PRKD2ACVR1B | |
| SCHEMBL8348254 | 0.81 | TGFBR1 (0.43) | TGFBR1PRKD3PRKD1PRKD2ACVR1B | |
| SCHEMBL8345672 | 0.80 | TGFBR1 (0.42) | TGFBR1PRKD3PRKD1PRKD2ACVR1B | |
| SCHEMBL8348230 | 0.79 | TGFBR1 (0.46) | TGFBR1PRKD3PRKD1PRKD2ACVR1B | |
| SCHEMBL8346247 | 0.78 | TGFBR1 (0.59) | TGFBR1ACVR1BACVRL1BUB1 | |
| SCHEMBL8346301 | 0.78 | TGFBR1 (0.47) | TGFBR1ACVR1BACVRL1BUB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004024159-A1 | INHIBITORS OF TFGβ | SCIOS INC. (US) | 2004-03-25 | — | — | WO | disclosed |