Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 3/20 | 0.56 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.56 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.56 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.56 |
| ▸ | BUB1 | O43683 | 17/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8344963 | 0.88 | TGFBR1 (0.53) | TGFBR1PRKD3PRKD1PRKD2BUB1 | |
| SCHEMBL8345332 | 0.86 | TGFBR1 (0.59) | TGFBR1PRKD3PRKD1PRKD2BUB1 | |
| SCHEMBL8345668 | 0.85 | TGFBR1 (0.40) | TGFBR1PRKD3PRKD1PRKD2BUB1 | |
| SCHEMBL8344361 | 0.82 | TGFBR1 (0.55) | TGFBR1PRKD3PRKD1PRKD2BUB1 | |
| SCHEMBL8345684 | 0.80 | TGFBR1 (0.63) | TGFBR1PRKD3PRKD1PRKD2BUB1 | |
| SCHEMBL8347946 | 0.76 | FLT1 (0.43) | TGFBR1PRKD3PRKD1PRKD2BUB1 | |
| SCHEMBL8344966 | 0.75 | TGFBR1 (0.39) | TGFBR1PRKD3PRKD1PRKD2BUB1 | |
| SCHEMBL8344951 | 0.73 | AGER (0.39) | TGFBR1PRKD3PRKD1PRKD2BUB1 | |
| SCHEMBL8345584 | 0.73 | BUB1 (0.50) | BUB1 | |
| SCHEMBL8346587 | 0.73 | TGFBR1 (0.47) | TGFBR1PRKD3PRKD1PRKD2BUB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004024159-A1 | INHIBITORS OF TFGβ | SCIOS INC. (US) | 2004-03-25 | — | — | WO | disclosed |