SCHEMBL8345353

SCHEMBL8345353

COc1ccc2c(c1)CCC(N)(C(=O)O)C2

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRA2A P08913 3/20 0.47
SMN1; SMN2 Q16637 1/20 0.44
CXCR5 P32302 1/20 0.44
HSD17B10 Q99714 1/20 0.43
POLA1 P09884 2/20 0.43
ADRB2 P07550 1/20 0.42
HTR1A P08908 1/20 0.42
ADRA2B P18089 1/20 0.42
SLC6A2 P23975 1/20 0.42
HTR2C P28335 1/20 0.42
HRH1 P35367 1/20 0.42
OPRM1 P35372 1/20 0.42
OPRK1 P41145 1/20 0.42
HTR2B P41595 1/20 0.42
HTR5A P47898 1/20 0.42
SLC6A3 Q01959 1/20 0.42
SIGMAR1 Q99720 1/20 0.42
ESR1 P03372 1/20 0.41
ESR2 Q92731 1/20 0.41
DRD2 P14416 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7277494 0.88 CXCR5 (0.47) CXCR5HSD17B10POLA1HTR5ANPC1
Hydrochloric Acid SCHEMBL10913536 0.86 SMN1; SMN2 (0.51) ADRA2ASMN1; SMN2CXCR5HSD17B10ADRB2
SCHEMBL26402689 0.85 ADRA2A (0.40) ADRA2ASMN1; SMN2CXCR5HSD17B10POLA1
Hydrochloric Acid SCHEMBL26127895 0.84 ADRA2A (0.40) ADRA2ASMN1; SMN2CXCR5HSD17B10POLA1
Hydrochloric Acid SCHEMBL31435767 0.84 ADRA2A (0.40) ADRA2ASMN1; SMN2CXCR5HSD17B10POLA1
SCHEMBL29346148 0.83 KDM4E (0.36) ADRA2ACXCR5HSD17B10NPC1POLB
SCHEMBL3309945 0.83 ADRA2A (0.43) ADRA2ASMN1; SMN2HSD17B10ADRB2HTR1A
Hydrochloric Acid SCHEMBL3309941 0.82 ADRA2A (0.43) ADRA2ASMN1; SMN2HSD17B10ADRB2HTR1A
SCHEMBL3307587 0.82 SMN1; SMN2 (0.52) ADRA2ASMN1; SMN2CXCR5HSD17B10ADRB2
SCHEMBL26405589 0.81 ALOX15 (0.47) SMN1; SMN2CXCR5HSD17B10NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1999013062-A1 FACTORS VII FRAGMENTS AND ANALOGS THEREOF AND THEIR USE IN THE TREATMENT OF BLOOD CLOTTING DISORDERS NYCOMED IMAGING AS (NO) 1999-03-18 WO disclosed
WO-1999013063-A1 FACTOR VII FRAGMENTS AND ANALOGS THEREOF AND THEIR USE IN THE TREATMENT OF BLOOD CLOTTNG DISORDERS NYCOMED IMAGING AS (NO) 1999-03-18 WO disclosed
EP-0077122-B1 AMINO-SUBSTITUTED TETRALINS AND RELATED HOMOCYCLIC COMPOUNDS IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1986-05-07 EP disclosed
US-4464358-A OPIATE RECEPTOR ANTAGONISTS IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1984-08-07 US disclosed
EP-0077122-A2 Amino-substituted tetralins and related homocyclic compounds IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1983-04-20 EP disclosed