Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 6/20 | 0.44 |
| ▸ | CXCR3 | P49682 | 2/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | PRKAA2 | P54646 | 4/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6748396 | 0.74 | SMN1; SMN2 (0.43) | RORCCXCR3ROCK2PRKAA2TP53 | |
| SCHEMBL20903790 | 0.67 | RORC (0.56) | RORC | |
| SCHEMBL19864642 | 0.64 | TP53 (0.45) | ROCK2KDM1AHDAC1EPHX2ROCK1 | |
| SCHEMBL19864600 | 0.63 | TP53 (0.44) | ROCK2EPHX2ROCK1TP53DRD2 | |
| SCHEMBL19864629 | 0.63 | LMNA (0.44) | HDAC1EPHX2 | |
| SCHEMBL7445367 | 0.62 | ITGB3 (0.54) | — | |
| SCHEMBL7445376 | 0.62 | ITGB3 (0.54) | — | |
| SCHEMBL21277705 | 0.62 | RORC (0.51) | RORCCXCR3ROCK2KDM1AHDAC1 | |
| SCHEMBL21277672 | 0.62 | RORC (0.58) | RORC | |
| SCHEMBL18745170 | 0.61 | RORC (1.00) | RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004014389-A1 | 3,4-DIHYDROQUINOLIN-2-ONE, 5,6-FUSED OXAZIN-3-ONE, AND 5,6-FUSED THIAZIN-3-ONE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2004-02-19 | — | — | WO | disclosed |