SCHEMBL8345513

SCHEMBL8345513

Cn1nc(-c2c(F)cccc2Cl)nc1Cc1ccc(Cl)cc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.37
CASP3 P42574 1/20 0.37
RAB9A P51151 1/20 0.37
SENP8 Q96LD8 1/20 0.37
SENP7 Q9BQF6 1/20 0.37
SENP6 Q9GZR1 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
POLB P06746 1/20 0.36
GPBAR1 Q8TDU6 1/20 0.35
PSEN1 P49768 1/20 0.35
PSEN2 P49810 1/20 0.35
APH1B Q8WW43 1/20 0.35
NCSTN Q92542 1/20 0.35
APH1A Q96BI3 1/20 0.35
PSENEN Q9NZ42 1/20 0.35
NR1H2 P55055 1/20 0.35
NR1H3 Q13133 1/20 0.35
HDAC6 Q9UBN7 1/20 0.34
KMT2A Q03164 1/20 0.34
ATM Q13315 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8345336 0.91 NR1H2 (0.38) RAB9APOLBPSEN1PSEN2APH1B
SCHEMBL8346582 0.90 KMT2A (0.36) POLBPSEN1PSEN2APH1BNCSTN
SCHEMBL8343347 0.85 HCRTR1 (0.33) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL8342984 0.84 SMN1; SMN2 (0.36) L3MBTL1POLBKMT2AATMTP53
SCHEMBL8343159 0.83 PDE2A (0.36) L3MBTL1POLBKMT2APDE2APDE10A
SCHEMBL8344868 0.81 MET (0.37) NPC1RAB9APSEN1PSEN2APH1B
SCHEMBL6963345 0.79 NR1H2 (0.35) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL26766260 0.76 PDE2A (0.41) GPBAR1KMT2AATMPDE2APDE10A
SCHEMBL8345523 0.74 NPC1 (0.36) NPC1CASP3RAB9ASENP8SENP7
SCHEMBL8345626 0.74 NPC1 (0.36) NPC1CASP3RAB9ASENP8SENP7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5892048-A INSECTICIDES, MITICIDES NIPPON SODA CO., LTD. (JP) 1999-04-06 US disclosed
EP-0717039-A1 NOVEL TRIAZOLE COMPOUND, PROCESS FOR PRODUCING THE SAME, AND PEST CONTROL AGENT NIPPON SODA CO., LTD. (JP) 1996-06-19 EP disclosed