SCHEMBL8345336

SCHEMBL8345336

Cn1nc(-c2c(Cl)cccc2Cl)nc1Cc1ccc(Cl)cc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR1H2 P55055 1/20 0.38
NR1H3 Q13133 1/20 0.38
HDAC6 Q9UBN7 1/20 0.37
DRD2 P14416 1/20 0.36
TBXA2R P21731 1/20 0.36
SMN1; SMN2 Q16637 2/20 0.35
HTR6 P50406 1/20 0.35
ENPP2 Q13822 1/20 0.35
MAPK1 P28482 1/20 0.35
RAB9A P51151 1/20 0.35
KMT2A Q03164 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
ADCY10 Q96PN6 1/20 0.34
PIK3CD O00329 1/20 0.34
PIK3R1 P27986 1/20 0.34
PIK3CA P42336 1/20 0.34
PIK3CB P42338 1/20 0.34
PIK3CG P48736 1/20 0.34
LMNA P02545 1/20 0.34
ADRA1A P35348 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8345513 0.91 NPC1 (0.37) NR1H2NR1H3HDAC6DRD2TBXA2R
SCHEMBL6963345 0.87 NR1H2 (0.35) NR1H2NR1H3HDAC6DRD2TBXA2R
SCHEMBL8346582 0.81 KMT2A (0.36) HDAC6SMN1; SMN2KMT2ALMNAPOLB
SCHEMBL8343347 0.76 HCRTR1 (0.33) SMN1; SMN2MAPK1KMT2ALMNATP53
SCHEMBL6971952 0.76 PIK3CD (0.34) HTR6PIK3CDPIK3R1PIK3CAPIK3CB
SCHEMBL8342984 0.75 SMN1; SMN2 (0.36) SMN1; SMN2MAPK1KMT2ATP53POLB
SCHEMBL8344868 0.72 MET (0.37) HDAC6RAB9APIK3CDPIK3R1PIK3CA
SCHEMBL8343159 0.71 PDE2A (0.36) SMN1; SMN2MAPK1KMT2ALMNAPOLB
SCHEMBL6975165 0.71 SMN1; SMN2 (0.41) SMN1; SMN2RAB9AKMT2ATDP1LMNA
SCHEMBL11296201 0.67 HTR6 (0.41) HTR6MAPK1ADCY10TP53POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5892048-A INSECTICIDES, MITICIDES NIPPON SODA CO., LTD. (JP) 1999-04-06 US disclosed
EP-0717039-A1 NOVEL TRIAZOLE COMPOUND, PROCESS FOR PRODUCING THE SAME, AND PEST CONTROL AGENT NIPPON SODA CO., LTD. (JP) 1996-06-19 EP disclosed