Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | TET3 | O43151 | 1/20 | 0.38 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.38 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8349629 | 0.92 | TAAR1 (0.47) | TAAR1ALDH1A1HPGDKDM4EATM | |
| SCHEMBL26108561 | 0.84 | KDM4E (0.44) | HTTALDH1A1HPGDKDM4EL3MBTL1 | |
| SCHEMBL27612097 | 0.84 | ALDH1A1 (0.45) | TAAR1ALDH1A1HPGDKDM4EL3MBTL1 | |
| SCHEMBL5312097 | 0.83 | TAAR1 (0.46) | TAAR1PKMALDH1A1HPGDKDM4E | |
| SCHEMBL15297183 | 0.82 | HPGD (0.51) | ALDH1A1HPGDKDM4EL3MBTL1POLB | |
| SCHEMBL8347572 | 0.77 | TAAR1 (0.42) | TAAR1HTTHPGDSLC6A2SLC6A4 | |
| SCHEMBL7724232 | 0.75 | PRMT1 (0.45) | HTTALDH1A1HPGDTDP1MITF | |
| SCHEMBL8350583 | 0.75 | KMT2A (0.52) | PKMHTTALDH1A1HPGDKDM4E | |
| SCHEMBL8351459 | 0.73 | NAMPT (0.58) | PKMHTTALDH1A1HPGDKDM4E | |
| SCHEMBL26485285 | 0.72 | HPGD (0.43) | ALDH1A1HPGDSLC6A3MAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5935776-A | 2,5-BIS(4-(3-N,N,-DIMETHYLAMINOPROPYLAMIDINO)PHENYL)FURAN OR PHARMACEUTICALLY ACCEPTABLE SALT AND DILUENT OR CARRIER AS VIRICIDE TO SUPPRESS BINDING OF REV PROTEIN TO MESSENGER RNAS THUS SUPPRESSING REPLICATION OF HUMAN IMMUNODEFICIENCY VIRUS | UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER (US) | 1999-08-10 | — | — | US | claimed |
| US-5935776-A | 2,5-BIS(4-(3-N,N,-DIMETHYLAMINOPROPYLAMIDINO)PHENYL)FURAN OR PHARMACEUTICALLY ACCEPTABLE SALT AND DILUENT OR CARRIER AS VIRICIDE TO SUPPRESS BINDING OF REV PROTEIN TO MESSENGER RNAS THUS SUPPRESSING REPLICATION OF HUMAN IMMUNODEFICIENCY VIRUS | UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER (US) | 1999-08-10 | — | — | US | disclosed |