Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 19/20 | 0.69 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8025367 | 0.89 | PTGS2 (0.58) | PTGS2PTGS1 | |
| SCHEMBL6149802 | 0.83 | PTGS2 (0.62) | PTGS2PTGS1 | |
| Sulfamide SCHEMBL4639044 | 0.83 | PTGS2 (0.81) | PTGS2PTGS1 | |
| SCHEMBL215052 | 0.82 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL8622571 | 0.81 | PTGS2 (0.65) | PTGS2PTGS1 | |
| SCHEMBL7773789 | 0.80 | PTGS2 (0.50) | PTGS2PTGS1 | |
| SCHEMBL8350251 | 0.80 | PTGS2 (0.69) | PTGS2PTGS1 | |
| SCHEMBL8594582 | 0.79 | PTGS2 (0.48) | PTGS2PTGS1 | |
| SCHEMBL7860659 | 0.78 | PTGS2 (0.69) | PTGS2PTGS1 | |
| SCHEMBL8348992 | 0.76 | PTGS2 (0.69) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5932598-A | NOVEL SUBSTITUTED SULFONAMIDE COMPOUNDS USEFUL AS PRODRUGS; ADMINISTERING TO TREAT INFLAMMATION-ASSOCIATED PAIN DUE TO CANCER, DENTAL PAIN; CYCLOOXYGENASE-2 INHIBITORS | G. D. SEARLE & CO. (US) | 1999-08-03 | — | — | US | disclosed |