Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.76 |
| ▸ | ATM | Q13315 | 1/20 | 0.76 |
| ▸ | SNCA | P37840 | 1/20 | 0.64 |
| ▸ | F3 | P13726 | 2/20 | 0.58 |
| ▸ | GSK3B | P49841 | 2/20 | 0.55 |
| ▸ | BACE1 | P56817 | 1/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | BCHE | P06276 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.54 |
| ▸ | RELA | Q04206 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 4-Methoxycinnamic Acid SCHEMBL8346565 | 1.00 | THRB (0.76) | THRBATMSNCAF3GSK3B | |
| 4-Methoxycinnamic Acid SCHEMBL5277771 | 0.88 | THRB (0.81) | THRBATMF3GSK3BBACE1 | |
| SCHEMBL15014206 | 0.88 | THRB (0.81) | THRBATMF3GSK3BBACE1 | |
| 4-Methoxycinnamic Acid SCHEMBL58700 | 0.87 | THRB (1.00) | THRBATMF3GSK3BBACE1 | |
| 4-Methoxycinnamic Acid SCHEMBL58699 | 0.87 | THRB (1.00) | THRBATMF3GSK3BBACE1 | |
| SCHEMBL992032 | 0.87 | ALDH1A1 (0.67) | THRBATMSNCAHDAC2HDAC3 | |
| 4-Methoxycinnamic Acid SCHEMBL12473722 | 0.87 | THRB (1.00) | THRBATMF3GSK3BBACE1 | |
| SCHEMBL992033 | 0.87 | ALDH1A1 (0.67) | THRBATMSNCAHDAC2HDAC3 | |
| SCHEMBL8346575 | 0.87 | SNCA (0.59) | THRBATMSNCAF3GSK3B | |
| 4-Methoxycinnamic Acid SCHEMBL8500105 | 0.85 | THRB (0.96) | THRBATMF3GSK3BBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999012034-A1 | AMINE COMPOUNDS AND COMBINATORIAL LIBRARIES COMPRISING SAME | ISIS PHARMACEUTICALS, INC. (US) | 1999-03-11 | — | — | WO | disclosed |