SCHEMBL8346757

SCHEMBL8346757

O=C(O)c1cc(Cl)c2c(c1Cl)C1(CCS2)OCCO1

nearest known ligand 0.33

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
HTT P42858 1/20 0.33
TSHR P16473 2/20 0.31
POLB P06746 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9037686 0.80 RXRA (0.35) TSHRPOLB
SCHEMBL8891345 0.77
SCHEMBL8346524 0.74 HTT (0.36) HTTTSHRPOLB
SCHEMBL8344681 0.74 RXRA (0.30)
SCHEMBL6726076 0.71 PTGS1 (0.32)
SCHEMBL6721524 0.70 RXRA (0.35) TSHRPOLB
SCHEMBL9036741 0.68 RARA (0.34)
SCHEMBL8122883 0.66 HTT (0.34) HTT
SCHEMBL6973404 0.61 NOTUM (0.35) HTTTSHRPOLB
SCHEMBL8888008 0.60 RARB (0.51) HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5952266-A HERBICIDES E. I. DU PONT DE NEMOURS AND COMPANY (US) 1999-09-14 US disclosed
WO-1997001550-A1 HERBICIDAL KETALS AND SPIROCYCLES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1997-01-16 WO disclosed