Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | PTPRC | P08575 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.42 |
| ▸ | TNKS | O95271 | 2/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26923012 | 0.74 | KDM4E (0.50) | ALOX5NISCHPTGS2PTPRCALDH1A1 | |
| SCHEMBL8350674 | 0.72 | AHR (0.45) | ALDH1A1MAPTKDM4EHPGD | |
| SCHEMBL8352597 | 0.71 | GSTP1 (0.47) | ALOX5NISCHCA2CA9 | |
| SCHEMBL8351255 | 0.70 | PDE4A (0.50) | MAPTKDM4E | |
| SCHEMBL22162812 | 0.69 | CA12 (0.58) | ALOX5NISCHPTGS2PTPRCALDH1A1 | |
| SCHEMBL4806998 | 0.69 | PTGS2 (0.47) | NISCHPTGS2PTPRCALDH1A1CA12 | |
| SCHEMBL2259811 | 0.69 | PTGS2 (0.45) | ALOX5NISCHPTGS2PTPRCALDH1A1 | |
| SCHEMBL8347265 | 0.69 | AXL (0.42) | ALDH1A1CA12CA9MAPTHSD17B10 | |
| SCHEMBL6316764 | 0.68 | PTGS2 (0.87) | ALOX5PTGS2PTPRCALDH1A1CYP1A2 | |
| SCHEMBL11184600 | 0.68 | PDE10A (0.51) | NISCHPTGS2PTPRCALDH1A1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5861416-A | TREATMENT OF ASTHMA OR COUGH | MERRELL PHARMACEUTICALS INC. (US) | 1999-01-19 | — | — | US | disclosed |
| US-5824690-A | TREATING ASTHMA, COUGH | HOECHST MARION ROUSSEL INC. (US) | 1998-10-20 | — | — | US | disclosed |