Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.42 |
| ▸ | CFTR | P13569 | 1/20 | 0.41 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.41 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.38 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TDP2 | O95551 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8347616 | 0.79 | CYP1A2 (0.48) | SMN1; SMN2TDP2ALDH1A1KDM4EHPGD | |
| SCHEMBL8352597 | 0.77 | GSTP1 (0.47) | CA9NOTUM | |
| SCHEMBL27532143 | 0.75 | BACE1 (0.43) | CLK4KDM4EGAAMAP2K1LMNA | |
| SCHEMBL8352439 | 0.75 | TDP2 (0.45) | TDP2PIM1KDRNOTUM | |
| SCHEMBL8350109 | 0.74 | PARP10 (0.47) | MAPTPARP10PARP11NOTUM | |
| SCHEMBL8355493 | 0.72 | NISCH (0.40) | TDP2KDRMAP2K1PRKAA1LMNA | |
| SCHEMBL8350674 | 0.71 | AHR (0.45) | ALDH1A1KDM4EGAAHPGDGSK3A | |
| SCHEMBL8351255 | 0.69 | PDE4A (0.50) | KDM4EMAPT | |
| SCHEMBL89023 | 0.68 | ALOX15 (0.56) | TYRO3NTRK2CLK4DYRK1BTDP2 | |
| SCHEMBL8349890 | 0.68 | LTK (0.46) | CLK4SMN1; SMN2ALDH1A1KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5861416-A | TREATMENT OF ASTHMA OR COUGH | MERRELL PHARMACEUTICALS INC. (US) | 1999-01-19 | — | — | US | disclosed |
| US-5824690-A | TREATING ASTHMA, COUGH | HOECHST MARION ROUSSEL INC. (US) | 1998-10-20 | — | — | US | disclosed |