Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 13/20 | 0.41 |
| ▸ | ACVR1B | P36896 | 10/20 | 0.41 |
| ▸ | ACVRL1 | P37023 | 8/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 4/20 | 0.40 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8347940 | 0.90 | PTGER1 (0.42) | TGFBR1MRGPRX4PTGER1CYP3A4CYP2C9 | |
| SCHEMBL8348965 | 0.88 | TGFBR1 (0.39) | TGFBR1ACVR1BACVRL1MRGPRX4PTGER1 | |
| SCHEMBL8344954 | 0.86 | PTGER1 (0.42) | TGFBR1ACVR1BACVRL1PTGER1CYP3A4 | |
| SCHEMBL8348247 | 0.83 | FLT1 (0.41) | TGFBR1ACVR1BACVRL1PTGER1CYP3A4 | |
| SCHEMBL8347263 | 0.83 | TGFBR1 (0.42) | TGFBR1ACVR1BACVRL1PTGER1CYP3A4 | |
| SCHEMBL5955198 | 0.82 | TGFBR1 (0.48) | TGFBR1ACVR1BACVRL1MRGPRX4PTGER1 | |
| SCHEMBL8346060 | 0.79 | LRRK2 (0.49) | TGFBR1ACVR1BACVRL1PTGER1CYP3A4 | |
| SCHEMBL8344535 | 0.79 | TGFBR1 (0.41) | TGFBR1ACVR1BACVRL1CYP3A4ACVR1 | |
| SCHEMBL13649279 | 0.79 | PTGER1 (0.50) | TGFBR1ACVR1BACVRL1MRGPRX4PTGER1 | |
| SCHEMBL13649278 | 0.78 | TGFBR1 (0.53) | TGFBR1ACVR1BACVRL1PTGER1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004024159-A1 | INHIBITORS OF TFGβ | SCIOS INC. (US) | 2004-03-25 | — | — | WO | disclosed |