Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 8/20 | 0.42 |
| ▸ | BUB1 | O43683 | 5/20 | 0.40 |
| ▸ | ACVRL1 | P37023 | 3/20 | 0.39 |
| ▸ | ACVR1B | P36896 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.38 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8347940 | 0.91 | PTGER1 (0.42) | TGFBR1BUB1CYP3A4PTGER1CYP2C9 | |
| SCHEMBL8348247 | 0.91 | FLT1 (0.41) | TGFBR1BUB1ACVRL1ACVR1BKCNH2 | |
| SCHEMBL5955392 | 0.89 | NUDT1 (0.50) | TGFBR1BUB1ACVRL1ACVR1BBMPR1A | |
| SCHEMBL8344954 | 0.88 | PTGER1 (0.42) | TGFBR1BUB1ACVRL1ACVR1BCYP3A4 | |
| SCHEMBL8348965 | 0.85 | TGFBR1 (0.39) | TGFBR1BUB1ACVRL1ACVR1BCYP3A4 | |
| SCHEMBL8347944 | 0.84 | TGFBR1 (0.50) | TGFBR1BUB1ACVRL1ACVR1BCYP3A4 | |
| SCHEMBL8345668 | 0.83 | TGFBR1 (0.40) | TGFBR1BUB1ACVRL1ACVR1BKCNH2 | |
| SCHEMBL8347266 | 0.83 | TGFBR1 (0.41) | TGFBR1ACVRL1ACVR1BCYP3A4ACVR1 | |
| SCHEMBL5955198 | 0.82 | TGFBR1 (0.48) | TGFBR1BUB1ACVRL1ACVR1BCYP3A4 | |
| SCHEMBL8347168 | 0.81 | TGFBR1 (0.47) | TGFBR1BUB1ACVRL1ACVR1BFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004024159-A1 | INHIBITORS OF TFGβ | SCIOS INC. (US) | 2004-03-25 | — | — | WO | disclosed |