Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 8/20 | 0.40 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.39 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.39 |
| ▸ | BUB1 | O43683 | 1/20 | 0.39 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.38 |
| ▸ | PTGER1 | P34995 | 6/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.37 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.37 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.37 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8344954 | 0.94 | PTGER1 (0.42) | FLT1KDRTGFBR1TGFBR2PRKD3 | |
| SCHEMBL8347263 | 0.91 | TGFBR1 (0.42) | FLT1KDRTGFBR1BUB1PTGER1 | |
| SCHEMBL8348965 | 0.89 | TGFBR1 (0.39) | FLT1KDRTGFBR1TGFBR2PRKD3 | |
| SCHEMBL8345668 | 0.87 | TGFBR1 (0.40) | TGFBR1TGFBR2PRKD3PRKD1PRKD2 | |
| SCHEMBL8347168 | 0.86 | TGFBR1 (0.47) | FLT1TGFBR1TGFBR2PRKD3PRKD1 | |
| SCHEMBL8347946 | 0.86 | FLT1 (0.43) | FLT1KDRTGFBR1TGFBR2PRKD3 | |
| SCHEMBL8347940 | 0.85 | PTGER1 (0.42) | TGFBR1BUB1PTGER1CYP2C9CYP3A4 | |
| SCHEMBL8344966 | 0.84 | TGFBR1 (0.39) | FLT1KDRTGFBR1TGFBR2PRKD3 | |
| SCHEMBL8344535 | 0.84 | TGFBR1 (0.41) | TGFBR1TGFBR2PRKD3PRKD1PRKD2 | |
| SCHEMBL8347266 | 0.83 | TGFBR1 (0.41) | TGFBR1PTGER1CYP2C9ACVR1BACVRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004024159-A1 | INHIBITORS OF TFGβ | SCIOS INC. (US) | 2004-03-25 | — | — | WO | disclosed |