SCHEMBL8347464

SCHEMBL8347464

C[Si](C)(C)CCc1ccccc1N(c1ccccc1)c1ccccc1

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.33
TP53 P04637 1/20 0.32
ALDH1A1 P00352 5/20 0.32
TSHR P16473 2/20 0.32
TDP1 Q9NUW8 2/20 0.32
GLA P06280 1/20 0.32
POLB P06746 1/20 0.32
KDM4E B2RXH2 2/20 0.31
CYP1A2 P05177 1/20 0.31
CYP3A4 P08684 1/20 0.31
CYP2D6 P10635 1/20 0.31
CYP2C9 P11712 1/20 0.31
CYP2C19 P33261 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
CHRM2 P08172 1/20 0.31
HTR1A P08908 1/20 0.31
ADRA2A P08913 1/20 0.31
CHRM1 P11229 1/20 0.31
DRD1 P21728 1/20 0.31
SLC6A2 P23975 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL806152 0.82 ALDH1A1 (0.39) MAPTTP53ALDH1A1TSHRTDP1
SCHEMBL8347602 0.82 TP53 (0.31) TP53POLBSMN1; SMN2
SCHEMBL24631166 0.81 TP53 (0.39) MAPTTP53ALDH1A1TSHRTDP1
SCHEMBL8329493 0.80 TP53 (0.32) TP53SMN1; SMN2
SCHEMBL5809365 0.78 CYP3A4 (0.42) MAPTTP53CYP3A4CYP2D6CYP2C9
SCHEMBL7895277 0.77 ALDH1A1 (0.42) MAPTTP53ALDH1A1TSHRTDP1
SCHEMBL30306601 0.77 ALDH1A1 (0.42) MAPTTP53ALDH1A1TSHRTDP1
SCHEMBL28041959 0.76 LIPG (0.49) KCNH2
SCHEMBL28765851 0.76 TDP1 (0.41) MAPTTP53ALDH1A1TSHRTDP1
SCHEMBL7922788 0.75 LIPG (0.51) KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5888690-A Electrophotographic photosensitive member, a process-cartridge inclusive thereof, and an image forming apparatus CANON KABUSHIKI KAISHA (JP) 1999-03-30 US disclosed
US-5879847-A Electrophotographic photosensitive member, a process-cartridge inclusive thereof and an image forming apparatus CANON KABUSHIKI KAISHA (JP) 1999-03-09 US disclosed
US-5840816-A Method of manufacturing a polysiloxane charge transporting material DOW CORNING TORAY SILICONE CO., LTD. (JP) 1998-11-24 US disclosed