SCHEMBL8347602

SCHEMBL8347602

CCO[Si](C)(CCc1ccccc1N(c1ccccc1)c1ccccc1)OCC

nearest known ligand 0.33

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
TP53 P04637 1/20 0.31
POLB P06746 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8329493 0.86 TP53 (0.32) TP53SMN1; SMN2
SCHEMBL8347464 0.82 MAPT (0.33) TP53POLBSMN1; SMN2
SCHEMBL8351452 0.81 TP53 (0.30) TP53SMN1; SMN2
SCHEMBL8348239 0.79 CYP4F2 (0.31)
SCHEMBL2399088 0.78 FAAH (0.40)
SCHEMBL806152 0.76 ALDH1A1 (0.39) TP53
SCHEMBL24631166 0.75 TP53 (0.39) TP53
SCHEMBL3337265 0.74 CYP4F2 (0.32)
SCHEMBL27449351 0.74 MAPT (0.35) TP53
SCHEMBL2872464 0.73 TDP1 (0.41) TP53SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5888690-A Electrophotographic photosensitive member, a process-cartridge inclusive thereof, and an image forming apparatus CANON KABUSHIKI KAISHA (JP) 1999-03-30 US disclosed
US-5879847-A Electrophotographic photosensitive member, a process-cartridge inclusive thereof and an image forming apparatus CANON KABUSHIKI KAISHA (JP) 1999-03-09 US disclosed
US-5840816-A Method of manufacturing a polysiloxane charge transporting material DOW CORNING TORAY SILICONE CO., LTD. (JP) 1998-11-24 US disclosed
US-5824443-A Method of manufacturing sililcon-type charge transporting materials DOW CORNING ASIA, LTD. (JP) 1998-10-20 US disclosed