Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 8/20 | 0.36 |
| ▸ | CCND1 | P24385 | 8/20 | 0.36 |
| ▸ | CCNE2 | O96020 | 7/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 7/20 | 0.36 |
| ▸ | CDK2 | P24941 | 7/20 | 0.36 |
| ▸ | BCL2 | P10415 | 1/20 | 0.36 |
| ▸ | BAD | Q92934 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.34 |
| ▸ | GABRP | O00591 | 6/20 | 0.33 |
| ▸ | GABRD | O14764 | 6/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 6/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 6/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 6/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 6/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 6/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 6/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 6/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8350166 | 1.00 | CDK4 (0.36) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL8351551 | 0.91 | GABRP (0.43) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL8505897 | 0.89 | CCNE2 (0.37) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL7608894 | 0.89 | BCL2 (0.36) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL8329192 | 0.86 | BCL2 (0.36) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL8327392 | 0.86 | BCL2 (0.36) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL8330780 | 0.81 | CCNE2 (0.38) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL8783898 | 0.80 | CDK4 (0.33) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL8506845 | 0.80 | GABRP (0.44) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL8782500 | 0.79 | CCNE2 (0.32) | CDK4CCND1CCNE2CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0674631-B1 | SUBSTITUTED PYRAZOLES AS CRF ANTAGONISTS | PFIZER (US) | 1999-12-08 | — | — | EP | claimed |
| EP-0959074-A2 | Substituted pyrazoles as CRF antagonists | PFIZER INC. (US) | 1999-11-24 | — | — | EP | claimed |
| US-5705646-A | Substituted pyrazoles as CRF antagonists | PFIZER INC. (US) | 1998-01-06 | — | — | US | claimed |
| EP-0674631-A1 | SUBSTITUTED PYRAZOLES AS CRF ANTAGONISTS | PFIZER INC. (US) | 1995-10-04 | — | — | EP | claimed |
| WO-1994013661-A1 | SUBSTITUTED PYRAZOLES AS CRF ANTAGONISTS | PFIZER INC. (US) | 1994-06-23 | — | — | WO | claimed |
| EP-0959074-A2 | Substituted pyrazoles as CRF antagonists | PFIZER INC. (US) | 1999-11-24 | — | — | EP | disclosed |
| US-5958948-A | CORTICOTROPIN RELEASING FACTOR; THERAPY FOR STRESS | PFIZER, INC. (US) | 1999-09-28 | — | — | US | disclosed |
| US-5705646-A | Substituted pyrazoles as CRF antagonists | PFIZER INC. (US) | 1998-01-06 | — | — | US | disclosed |