Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE2 | O96020 | 16/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 16/20 | 0.38 |
| ▸ | CDK2 | P24941 | 16/20 | 0.38 |
| ▸ | BCL2 | P10415 | 1/20 | 0.34 |
| ▸ | BAD | Q92934 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 10/20 | 0.34 |
| ▸ | CCND1 | P24385 | 10/20 | 0.34 |
| ▸ | CCNB2 | O95067 | 4/20 | 0.34 |
| ▸ | CDK1 | P06493 | 4/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.34 |
| ▸ | CCNB3 | Q8WWL7 | 4/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8330693 | 0.91 | GABRB3 (0.42) | BCL2BAD | |
| SCHEMBL8506675 | 0.86 | OPRM1 (0.37) | BCL2BADOPRM1OPRD1OPRK1 | |
| SCHEMBL8587701 | 0.86 | GABRB3 (0.38) | BCL2BADOPRM1OPRD1OPRK1 | |
| SCHEMBL8326165 | 0.85 | OPRM1 (0.36) | BCL2BADOPRM1OPRD1OPRK1 | |
| SCHEMBL8329192 | 0.83 | BCL2 (0.36) | CCNE2CCNE1CDK2BCL2BAD | |
| SCHEMBL8327392 | 0.83 | BCL2 (0.36) | CCNE2CCNE1CDK2BCL2BAD | |
| SCHEMBL8505197 | 0.83 | GABRB3 (0.41) | — | |
| SCHEMBL8347791 | 0.81 | CDK4 (0.36) | CCNE2CCNE1CDK2BCL2BAD | |
| SCHEMBL8350166 | 0.81 | CDK4 (0.36) | CCNE2CCNE1CDK2BCL2BAD | |
| SCHEMBL8328707 | 0.80 | GABRB3 (0.39) | BCL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0674631-B1 | SUBSTITUTED PYRAZOLES AS CRF ANTAGONISTS | PFIZER (US) | 1999-12-08 | — | — | EP | claimed |
| EP-0959074-A2 | Substituted pyrazoles as CRF antagonists | PFIZER INC. (US) | 1999-11-24 | — | — | EP | claimed |
| EP-0674631-A1 | SUBSTITUTED PYRAZOLES AS CRF ANTAGONISTS | PFIZER INC. (US) | 1995-10-04 | — | — | EP | claimed |
| WO-1994013661-A1 | SUBSTITUTED PYRAZOLES AS CRF ANTAGONISTS | PFIZER INC. (US) | 1994-06-23 | — | — | WO | claimed |
| EP-0674631-B1 | SUBSTITUTED PYRAZOLES AS CRF ANTAGONISTS | PFIZER (US) | 1999-12-08 | — | — | EP | disclosed |
| EP-0959074-A2 | Substituted pyrazoles as CRF antagonists | PFIZER INC. (US) | 1999-11-24 | — | — | EP | disclosed |
| US-5968944-A | TREATING STRESS AND ANXIETY RELATED DISORDERS | PFIZER INC. (US) | 1999-10-19 | — | — | US | disclosed |
| EP-0674631-A1 | SUBSTITUTED PYRAZOLES AS CRF ANTAGONISTS | PFIZER INC. (US) | 1995-10-04 | — | — | EP | disclosed |
| WO-1994013661-A1 | SUBSTITUTED PYRAZOLES AS CRF ANTAGONISTS | PFIZER INC. (US) | 1994-06-23 | — | — | WO | disclosed |