Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 4/20 | 0.53 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.53 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.53 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.53 |
| ▸ | AGPAT2 | O15120 | 10/20 | 0.50 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8348234 | 0.80 | TGFBR1 (0.53) | TGFBR1AGPAT2ABCG2MEN1KMT2A | |
| SCHEMBL8345329 | 0.79 | TGFBR1 (0.58) | TGFBR1PRKD3PRKD1PRKD2MEN1 | |
| SCHEMBL8346584 | 0.77 | TGFBR1 (0.59) | TGFBR1PRKD3PRKD1PRKD2AGPAT2 | |
| SCHEMBL8344305 | 0.76 | RECQL (0.39) | TGFBR1PRKD3PRKD1PRKD2AGPAT2 | |
| SCHEMBL8345332 | 0.74 | TGFBR1 (0.59) | TGFBR1PRKD3PRKD1PRKD2 | |
| SCHEMBL16424643 | 0.74 | RECQL (0.37) | TGFBR1PRKD3PRKD1PRKD2AGPAT2 | |
| SCHEMBL8345684 | 0.70 | TGFBR1 (0.63) | TGFBR1PRKD3PRKD1PRKD2CYP1A2 | |
| SCHEMBL29381400 | 0.69 | TGFBR1 (1.00) | TGFBR1PRKD3PRKD1PRKD2ABCG2 | |
| SCHEMBL411646 | 0.69 | TGFBR1 (1.00) | TGFBR1PRKD3PRKD1PRKD2ABCG2 | |
| SCHEMBL29361383 | 0.69 | TGFBR1 (1.00) | TGFBR1PRKD3PRKD1PRKD2ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004024159-A1 | INHIBITORS OF TFGβ | SCIOS INC. (US) | 2004-03-25 | — | — | WO | disclosed |