Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 6/20 | 0.62 |
| ▸ | MMP10 | P09238 | 1/20 | 0.50 |
| ▸ | MMP9 | P14780 | 1/20 | 0.50 |
| ▸ | MMP8 | P22894 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8349445 | 0.86 | MMP13 (0.74) | MMP13MMP10MMP9MMP8SMN1; SMN2 | |
| SCHEMBL8357434 | 0.86 | MMP13 (0.86) | MMP13MMP10MMP9MMP8L3MBTL1 | |
| SCHEMBL8349489 | 0.86 | MMP13 (0.62) | MMP13MMP10MMP9MMP8SMN1; SMN2 | |
| SCHEMBL5615854 | 0.86 | MMP13 (0.86) | MMP13MMP10MMP9MMP8SMN1; SMN2 | |
| SCHEMBL8348635 | 0.83 | MMP13 (0.57) | MMP13MMP10MMP9MMP8ALDH1A1 | |
| SCHEMBL8349486 | 0.83 | MMP13 (0.57) | MMP13MMP10MMP9MMP8SMN1; SMN2 | |
| SCHEMBL5616139 | 0.82 | MMP13 (0.78) | MMP13MMP10MMP9MMP8SMN1; SMN2 | |
| SCHEMBL8358830 | 0.81 | MMP13 (0.77) | MMP13MMP10MMP9MMP8 | |
| SCHEMBL8347568 | 0.80 | MMP13 (0.61) | MMP13MMP10MMP9MMP8SMN1; SMN2 | |
| SCHEMBL14602302 | 0.80 | MMP13 (0.75) | MMP13MMP10MMP9MMP8SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004060883-A1 | PYRIMIDINE-4,6-DICARBOXYLIC ACID DIAMIDES FOR USE AS SELECTIVE MMP 13 INHIBITORS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-07-22 | — | — | WO | disclosed |