Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 6/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 8/20 | 0.47 |
| ▸ | NPC1 | O15118 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MMP10 | P09238 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8348721 | 0.87 | MMP13 (0.77) | MMP13HPGDALDH1A1RAB9ANPC1 | |
| SCHEMBL8348532 | 0.87 | MMP13 (0.57) | MMP13HPGDALDH1A1RAB9ANPC1 | |
| SCHEMBL8348345 | 0.83 | MMP13 (0.62) | MMP13HPGDALDH1A1SMN1; SMN2MMP10 | |
| SCHEMBL8348635 | 0.83 | MMP13 (0.57) | MMP13ALDH1A1MEN1KMT2AMMP10 | |
| SCHEMBL8347568 | 0.82 | MMP13 (0.61) | MMP13ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL8357434 | 0.81 | MMP13 (0.86) | MMP13MMP10MMP9MMP8 | |
| SCHEMBL8349716 | 0.80 | MMP13 (0.53) | MMP13ALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL8349445 | 0.80 | MMP13 (0.74) | MMP13HPGDALDH1A1RAB9ANPC1 | |
| SCHEMBL8335113 | 0.79 | SMN1; SMN2 (0.64) | MMP13HPGDALDH1A1RAB9ANPC1 | |
| SCHEMBL8349714 | 0.78 | MMP13 (0.61) | MMP13HPGDALDH1A1MMP10MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004060883-A1 | PYRIMIDINE-4,6-DICARBOXYLIC ACID DIAMIDES FOR USE AS SELECTIVE MMP 13 INHIBITORS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-07-22 | — | — | WO | disclosed |