Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 2/20 | 0.78 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | MTHFD1 | P11586 | 3/20 | 0.57 |
| ▸ | SOST | Q9BQB4 | 1/20 | 0.57 |
| ▸ | MTHFD2 | P13995 | 3/20 | 0.51 |
| ▸ | FPGS | Q05932 | 2/20 | 0.51 |
| ▸ | ATIC | P31939 | 2/20 | 0.50 |
| ▸ | TYMS | P04818 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Leucovorin SCHEMBL21632556 | 0.99 | DHFR (0.80) | DHFRLMNAMTHFD1SOSTMTHFD2 | |
| Levoleucovorin SCHEMBL571901 | 0.99 | DHFR (0.80) | DHFRLMNAMTHFD1SOSTMTHFD2 | |
| Leucovorin SCHEMBL5132046 | 0.99 | DHFR (0.80) | DHFRLMNAMTHFD1SOSTMTHFD2 | |
| Leucovorin SCHEMBL8349 | 0.99 | DHFR (0.80) | DHFRLMNAMTHFD1SOSTMTHFD2 | |
| Leucovorin SCHEMBL8350 | 0.99 | DHFR (0.80) | DHFRLMNAMTHFD1SOSTMTHFD2 | |
| Leucovorin SCHEMBL4708750 | 0.99 | DHFR (0.80) | DHFRLMNAMTHFD1SOSTMTHFD2 | |
| Leucovorin SCHEMBL571902 | 0.99 | DHFR (0.80) | DHFRLMNAMTHFD1SOSTMTHFD2 | |
| Folinic Acid SCHEMBL29369091 | 0.99 | DHFR (0.80) | DHFRLMNAMTHFD1SOSTMTHFD2 | |
| Leucovorin SCHEMBL9054117 | 0.98 | DHFR (0.78) | DHFRLMNAMTHFD1SOSTMTHFD2 | |
| Leucovorin SCHEMBL16207660 | 0.98 | DHFR (0.78) | DHFRLMNAMTHFD1SOSTMTHFD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0432441-B1 | Process for the preparation of optically pure diastereoisomers of tetrahydrofolate compounds | AMERICAN CYANAMID CO (US) | 1996-06-26 | — | — | EP | disclosed |
| EP-0416232-B1 | Stable injectable pharmaceutical formulation for folic acid and leucovorin salts and method | AMERICAN CYANAMID CO (US) | 1995-08-16 | — | — | EP | disclosed |
| US-5334535-A | Process for the preparation of optically pure diastereoisomers of tetrahydrofolate compounds using 10-formyltetrahydrofolate synthetase from clostridium | AMERICAN CYANAMID COMPANY (US) | 1994-08-02 | — | — | US | disclosed |
| US-5173488-A | Tromethamine and monothioglycerol as buffers and antioxidants | AMERICAN CYANAMID COMPANY (US) | 1992-12-22 | — | — | US | disclosed |
| EP-0432441-A1 | Process for the preparation of optically pure diastereoisomers of tetrahydrofolate compounds | AMERICAN CYANAMID COMPANY (US) | 1991-06-19 | — | — | EP | disclosed |
| EP-0416232-A2 | Stable injectable pharmaceutical formulation for folic acid and leucovorin salts and method | AMERICAN CYANAMID COMPANY (US) | 1991-03-13 | — | — | EP | disclosed |