Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.66 |
| ▸ | KLK7 | P49862 | 6/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8348983 | 0.99 | TSHR (0.64) | TSHRKLK7NPC1RAB9AMAPK1 | |
| SCHEMBL8346775 | 0.75 | TSHR (0.58) | TSHRKLK7MEN1KMT2AALDH1A1 | |
| SCHEMBL8348907 | 0.71 | TSHR (0.51) | TSHRNPC1RAB9ALMNAMEN1 | |
| SCHEMBL18648119 | 0.70 | TSHR (0.67) | TSHRNPC1RAB9AEPHX1MEN1 | |
| SCHEMBL6762194 | 0.70 | TSHR (0.55) | TSHRNPC1RAB9AEPHX1 | |
| SCHEMBL16936035 | 0.69 | KLK7 (1.00) | TSHRKLK7NPC1RAB9AKMT2A | |
| SCHEMBL30846710 | 0.67 | KMT2A (0.57) | TSHRKLK7NPC1RAB9AMAPK1 | |
| SCHEMBL18354572 | 0.66 | KLK7 (1.00) | KLK7MEN1KMT2ATDP1ALDH1A1 | |
| SCHEMBL7384878 | 0.64 | DRD2 (0.41) | TSHRNPC1RAB9AEPHX1 | |
| SCHEMBL16946225 | 0.64 | KLK7 (1.00) | KLK7ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003101941-A2 | ALPHA ACYLOXYACETAMIDES FOR KALLIKREIN AND UROKINASE INHIBITION | GENZYME CORPORATION (US) | 2003-12-11 | — | — | WO | disclosed |