Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KRAS | P01116 | 1/20 | 0.44 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7250906 | 0.75 | MEN1 (0.54) | TSHRHPGDHTTRECQLMEN1 | |
| SCHEMBL8346775 | 0.74 | TSHR (0.58) | TSHRHTTMEN1ALDH1A1KMT2A | |
| SCHEMBL8348983 | 0.72 | TSHR (0.64) | TSHRLMNANPC1RAB9A | |
| SCHEMBL8349072 | 0.71 | TSHR (0.66) | TSHRHPGDMEN1ALDH1A1LMNA | |
| SCHEMBL7251407 | 0.69 | HPGD (0.46) | TSHRHPGDHTTRECQLMEN1 | |
| SCHEMBL27798619 | 0.69 | SOS1 (0.80) | TSHRHPGDHTTRECQLMEN1 | |
| SCHEMBL7649209 | 0.69 | SOS1 (0.80) | TSHRHPGDHTTRECQLMEN1 | |
| SCHEMBL7250903 | 0.69 | TSHR (0.46) | TSHRL3MBTL1MEN1ALDH1A1MAPT | |
| SCHEMBL19710653 | 0.68 | HPGD (0.69) | HPGDHTTRECQLNPY5RMEN1 | |
| SCHEMBL21489920 | 0.68 | HPGD (0.69) | HPGDHTTRECQLNPY5RMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003101941-A2 | ALPHA ACYLOXYACETAMIDES FOR KALLIKREIN AND UROKINASE INHIBITION | GENZYME CORPORATION (US) | 2003-12-11 | — | — | WO | disclosed |