Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.64 |
| ▸ | HPGD | P15428 | 4/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MMP13 | P45452 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8335479 | 0.89 | SMN1; SMN2 (0.52) | SMN1; SMN2HPGDL3MBTL1MEN1KMT2A | |
| SCHEMBL8335466 | 0.81 | MMP13 (0.72) | SMN1; SMN2HPGDMAPK1ALDH1A1KMT2A | |
| SCHEMBL8348532 | 0.81 | MMP13 (0.57) | SMN1; SMN2HPGDALDH1A1MEN1KMT2A | |
| SCHEMBL5617718 | 0.80 | ALDH1A1 (0.52) | SMN1; SMN2HPGDMAPK1ALDH1A1MEN1 | |
| SCHEMBL8348721 | 0.79 | MMP13 (0.77) | SMN1; SMN2HPGDALDH1A1MEN1KMT2A | |
| SCHEMBL8360152 | 0.79 | KMT2A (0.53) | HPGDMAPK1ALDH1A1MEN1KMT2A | |
| SCHEMBL8349486 | 0.79 | MMP13 (0.57) | SMN1; SMN2HPGDALDH1A1MEN1KMT2A | |
| SCHEMBL8335106 | 0.78 | MMP13 (0.50) | SMN1; SMN2HPGDMAPK1ALDH1A1MEN1 | |
| SCHEMBL8358827 | 0.76 | RAB9A (0.61) | HPGDMAPK1ALDH1A1MEN1KMT2A | |
| SCHEMBL4716678 | 0.75 | ALDH1A1 (0.54) | SMN1; SMN2HPGDMAPK1ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7166609-B2 | Pyrimidine-4,6-dicarboxylic acid diamides for selectively inhibiting collagenases | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-01-23 | — | — | US | disclosed |
| US-7166609-B2 | Pyrimidine-4,6-dicarboxylic acid diamides for selectively inhibiting collagenases | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-01-23 | — | — | US | disclosed |
| WO-2004041788-A1 | NOVEL PYRIMIDINE-4,6-DICARBOXAMIDES FOR THE SELECTIVE INHIBITION OF COLLAGENASES | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-05-21 | — | — | WO | disclosed |