Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8351735 | 1.00 | PKM (0.49) | PKMNPSR1MEN1KMT2APOLB | |
| SCHEMBL2605500 | 1.00 | PKM (0.49) | PKMNPSR1MEN1KMT2APOLB | |
| SCHEMBL27377437 | 0.88 | PKM (0.55) | PKMNPSR1MEN1KMT2APOLB | |
| SCHEMBL17103459 | 0.88 | PKM (0.55) | PKMNPSR1MEN1KMT2APOLB | |
| SCHEMBL17103461 | 0.88 | PKM (0.55) | PKMNPSR1MEN1KMT2APOLB | |
| SCHEMBL21087217 | 0.86 | CCR8 (0.61) | MEN1KMT2AMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL19294298 | 0.86 | CCR8 (0.61) | MEN1KMT2AMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL20489039 | 0.86 | FABP7 (0.43) | PKMNPSR1MEN1KMT2AL3MBTL1 | |
| SCHEMBL12055622 | 0.86 | LMNA (0.43) | MEN1KMT2APOLBL3MBTL1ALDH1A1 | |
| SCHEMBL760583 | 0.85 | ALDH1A1 (0.47) | NPSR1POLBMAPTALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6001841-A | ANTISENSE DIAGNOSTICS, THERAPEUTICS AND RESEARCH REAGENTS. | ISIS PHARMACEUTICALS, INC. (US) | 1999-12-14 | — | — | US | disclosed |
| EP-0693054-B1 | CYCLOALKYLHYDROXYUREAS AND THEIR USE AS LIPOXYGENASE INHIBITORS | PFIZER (US) | 1998-06-10 | — | — | EP | disclosed |
| US-5681858-A | Cycloalkyl hydroxyureas | PFIZER INC. (US) | 1997-10-28 | — | — | US | disclosed |
| EP-0689460-A1 | CYCLOBUTYL ANTISENSE OLIGONUCLEOTIDES, METHODS OF MAKING AND USE THEREOF | ISIS PHARMACEUTICALS, INC. (US) | 1996-01-03 | — | — | EP | disclosed |
| US-5359044-A | Diagnosis, chemical intermediates | ISIS PHARMACEUTICALS (US) | 1994-10-25 | — | — | US | disclosed |