Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.35 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1674894 | 0.82 | NPC1 (0.49) | APPLMNAPOLBNPC1RAB9A | |
| SCHEMBL11687255 | 0.81 | EPHX2 (0.46) | LMNAPOLBNPC1RAB9AMAPT | |
| SCHEMBL13169751 | 0.81 | APP (0.44) | APPLMNAPOLBNPC1RAB9A | |
| Hydrochloric Acid SCHEMBL27931881 | 0.81 | NPC1 (0.48) | APPLMNAPOLBNPC1RAB9A | |
| SCHEMBL25841055 | 0.79 | APP (0.43) | APPLMNAPOLBNPC1RAB9A | |
| SCHEMBL527094 | 0.78 | ALDH1A1 (0.46) | LMNAPOLBNPC1RAB9AMAPT | |
| SCHEMBL13169816 | 0.78 | LMNA (0.51) | APPLMNAPOLBNPC1RAB9A | |
| SCHEMBL11683088 | 0.77 | TP53 (0.57) | LMNAPOLBNPC1RAB9A | |
| SCHEMBL9926540 | 0.77 | APP (0.46) | APPLMNAPOLBNPC1RAB9A | |
| SCHEMBL6272101 | 0.75 | CYP3A4 (0.48) | APPPOLBMAPTMEN1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004058234-A2 | PHARMACEUTICAL COMBINATIONS OF PHTHALAZINE VEGF INHIBITORS AND BENZAMIDE HDAC INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 2004-07-15 | — | — | WO | disclosed |